منابع مشابه
Uncoupling protein, H+ transport and regulation.
The biochemical functions of uncoupling proteins (UCPs) are discussed with the view of UCP1 as a paradigm. In contrast with UCP1, the heterologous expression of UCP3 in yeast is found to result primarily in extra-mitochondrial deposits and thus is unsuitable for studying UCP3 function. On expression in Escherichia coli inclusion bodies, UCPs extracted and incorporated into vesicles showed no H(...
متن کاملThe mechanism of proton transport mediated by mitochondrial uncoupling proteins.
The effort to understand the mechanism of uncoupling by UCP has devolved into two models - the fatty acid protonophore model and the proton buffering model. Evidence for each hypothesis is summarized and evaluated. We also evaluate the obligatory requirement for fatty acids in UCP1-mediated uncoupling and the question of fatty acid affinity for UCP1. The structural bases of UCP transport functi...
متن کاملAlkylsulfonates as probes of uncoupling protein transport mechanism. Ion pair transport demonstrates that direct H(+) translocation by UCP1 is not necessary for uncoupling.
The mechanism of fatty acid-dependent uncoupling by mitochondrial uncoupling proteins (UCP) is still in debate. We have hypothesized that the anionic fatty acid head group is translocated by UCP, and the proton is transported electroneutrally in the bilayer by flip-flop of the protonated fatty acid. Alkylsulfonates are useful as probes of the UCP transport mechanism. They are analogues of fatty...
متن کاملWavenumber selection in coupled transport equations.
We study mechanisms for wavenumber selection in a minimal model for run-and-tumble dynamics. We show that nonlinearity in tumbling rates induces the existence of a plethora of traveling- and standing-wave patterns, as well as a subtle selection mechanism for the wavenumbers of spatio-temporally periodic waves. We comment on possible implications for rippling patterns observed in colonies of myx...
متن کاملModeling of thermodynamically coupled reaction-transport systems
Nonisothermal reaction-diffusion systems control the behavior of many transport and rate processes in physical, chemical and biological systems, such as pattern formation and chemical pumps. Considerable work has been published on mathematically coupled nonlinear differential equations by neglecting thermodynamic coupling between a chemical reaction and transport processes of mass and heat. Thi...
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ژورنال
عنوان ژورنال: Nature Chemical Biology
سال: 2017
ISSN: 1552-4450,1552-4469
DOI: 10.1038/nchembio.2351